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KMID : 0366220050400030188
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Korean Journal of Hematology
2005 Volume.40 No. 3 p.188 ~ p.191
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A Case of Extramedullary Progression Despite of Serologic Improvement in a Patient Treated with Thalidomide for Multiple Myeloma
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Yuh Young-Jin
Kim Hyun-Su
Park Young-Jung
Um Heung-Sik
Choi Sang-Bong
Lee Ban-Suck
Kim Sung-Rok
Han Tae-Hee
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Abstract
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Thalidomide is an anti-angiogenic agent widely used in patients with multiple myeloma. The response to therapy is commonly monitored using serum and/or urine M protein, as these are known to reflect the tumor burden. Although extramedullary plasmacytomas are tissues with high neovascularization, it has been suggested in some reports that the response to thalidomide in these patients may be inferior, despite changes in the serum M protein level. Herein, we report the case of a patient who newly developed hepatosplenic extramedullary plasmacytoma, despite reduction in the serum M protein level following thalidomide treatment.
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KEYWORD
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Thalidomide, Multiple Myeloma, Extramedullary plasmacytoma
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